Glucotrol (Glipizide), Amaryl (Glimepiride), and Diabeta (Glyburide)

April 5, 2023

Inability to use insulin properly is the hallmark of type 2 dibetes. Glipizide, glimepiride, and glyburide are medications used to help with this problem. These drugs are all sulfonylureas and work by encouraging the pancreatic beta cells to release more insulin. They may also increase cells’ ability to use insulin (decrease insulin resistance).

What are the usual doses for sulfonylurea medications?

  • Glucotrol (glipizide): 2.5 to 5.0 mg per day in the morning, by mouth
  • Amaryl (glimepiride): 1 to 2 mg once daily, by mouth
  • Diabeta (glyburide): 2.5 to 5.0 mg per day, by mouth

What are the common side effects of these 3 drugs?

  • Hypoglycemia (low blood sugar)
  • Dizziness
  • Confusion
  • Nervousness
  • Hunger
  • Weight gain
  • Upset stomach
  • Dark urine

How much do glipizide, glimepiride, and glyburide cost? 

  • Glucotrol (glipizide) ranges from $10 to $26 for a bottle of 180 tablets, strength 5.0 mg.
  • Amaryl (glimepiride) ranges from $7 to $35 for a bottle of 90 tablets, strength 4.0 mg.
  • Diabeta (glyburide) ranges from $9 to $16 for a bottle of 60 tablets, strength 5.0 mg.

How can I get a prescription for a sulfonylurea? 

All three drugs are prescription medications, which must have the approval of a physician or other licensed prescriber. QuickMD can help you manage your type 2 diabetes remotely by telemedicine and prescribe a sulfonylurea online though phone or video.

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