Wegovy (semaglutide) is generally well tolerated. Most patients experience mild symptoms—if any—and these symptoms get better over time as the body gets used to the medication.
Most common side effects
The main side effects of semaglutide are indigestion, diarrhea, constipation, gastroesophageal reflux (rising stomach acid), burping, and flatulence (gas).
Less common side effects
Rarer side effects include pancreatitis (inflammation of the pancreas) hypoglycemia, or low blood sugar, and allergic reactions. Signs and symptoms of pancreatitis include abdominal pain that may radiate through to the back, nausea and vomiting, fever, and bloating.
Semaglutide was originally developed as a treatment for diabetes under the name of Ozempic because it can lower blood sugar levels. Patients experiencing abnormally low blood sugar may have blurred vision, dizziness, shakiness, poor coordination, abnormal hunger or thirst, paleness, chills, or sweating.
Like all medications, Wegovy can cause allergic reactions in some susceptible individuals. Signs and symptoms of allergies can include rash, redness, itching, swelling of eyelids, face, hands and feet, or difficulty breathing.
Patients experiencing any of these side effects should consult their prescribing physician before taking the next dose of Wegovy.