What Are the Side Effects of Semaglutide? An In-Depth Look

August 27, 2024

4 minutes

Man on call with a QuickMD doctor experiencing semaglutide side effects

Semaglutide, the active ingredient in medications like Ozempic and Wegovy, has become a go-to option for managing type 2 diabetes and aiding in weight loss. While it’s highly effective, like any medication, semaglutide comes with potential side effects. Understanding these side effects can help you make informed decisions and manage any symptoms that might arise.

6 Common Side Effects of Semaglutide

Most people tolerate semaglutide well, but some may experience mild to moderate side effects, especially when they first start the medication. These side effects are typically related to the digestive system and may improve as your body adjusts.

1. Nausea

  • Why It Happens: Semaglutide slows digestion, which can lead to feelings of fullness and nausea, particularly after meals.
  • Management: Eating smaller, more frequent meals and avoiding rich, fatty foods can help reduce nausea.

2. Vomiting

  • Why It Happens: Some people experience vomiting, especially when their dose is increased or if they eat large meals.
  • Management: Gradually increasing the dose and staying hydrated can help manage this side effect​.

3. Diarrhea

  • Why It Happens: The way semaglutide affects digestion can sometimes lead to diarrhea.
  • Management: Staying hydrated and eating a balanced diet can help minimize this issue​.

4. Constipation

  • Why It Happens: On the flip side, semaglutide’s impact on digestion can slow things down too much, leading to constipation.
  • Management: Increasing your fiber intake and fluids, as well as staying active, can help​.

5. Fatigue

  • Why It Happens: Some people feel more tired than usual when starting semaglutide, possibly due to changes in blood sugar levels.
  • Management: Ensuring proper rest, balanced meals, and regular exercise can help maintain energy levels​.

6. Decreased Appetite

  • Why It Happens: One of the intended effects of semaglutide is appetite suppression, which helps with weight loss. However, this can sometimes lead to a very reduced appetite.
  • Management: Focus on eating nutrient-dense foods to ensure you’re getting enough vitamins and minerals.

4 Serious Side Effects of Semaglutide

While serious side effects are rare, they can occur and should be addressed immediately if they do.

Here are some to watch out for:

1. Pancreatitis

  • What It Is: This is an inflammation of the pancreas that can cause severe abdominal pain, nausea, and vomiting.
  • Action: Seek medical attention right away if you experience these symptoms.

2. Kidney Problems

  • What It Is: Semaglutide can lead to dehydration, which may cause or worsen kidney issues, especially in those with pre-existing conditions.
  • Action: Stay well-hydrated and monitor for signs like swelling or changes in urination​.

3. Gallbladder Disease

  • What It Is: Semaglutide may increase the risk of gallbladder problems, such as gallstones.
  • Action: Be aware of symptoms like severe stomach pain, nausea, or jaundice, and consult your healthcare provider if they occur.

4. Thyroid Tumors

  • What It Is: There’s a small risk of developing thyroid tumors, including cancer, particularly in those with a family history of thyroid cancer.
  • Action: Discuss your medical history with your doctor and report any neck swelling or difficulty swallowing​.

Understanding the common and severe side effects of semaglutide can help you better navigate your treatment. However, you might still wonder why you feel particularly unwell when starting this medication. 

This leads us to a crucial question: Why do I feel so bad on semaglutide?

Why Do I Feel So Bad on Semaglutide?

Feeling unwell after starting semaglutide is common, especially during the initial weeks. Here’s why:

  1. Adjustment Period: Your body is getting used to semaglutide, which slows digestion and affects blood sugar. This adjustment can lead to nausea, fatigue, and other discomforts as your system adapts.
  2. Digestive Reactions: Semaglutide often causes gastrointestinal issues like nausea, diarrhea, or constipation, which are typical as your digestive system slows down​.
  3. Appetite Changes: The drug reduces appetite, potentially leading to fatigue if you’re not consuming enough nutrients.
  4. Blood Sugar Fluctuations: Changes in blood sugar levels can make you feel shaky or lightheaded, adding to the feeling of discomfort​.

Managing These Symptoms

  • Start Low: Gradually increasing the dose can help ease the transition.
  • Smart Eating: Opt for small, frequent meals that are gentle on your stomach.
  • Stay Hydrated: Drink plenty of water to help with digestion and overall well-being.

Managing Semaglutide Side Effects with Support

Managing side effects effectively requires regular communication with your healthcare provider. 

At QuickMD, we offer convenient online consultations to help you navigate your treatment with semaglutide. Whether you’re starting this medication or need guidance on managing side effects, our experienced providers are here to support you every step of the way.

Disclaimer

Disclaimer Articles on this website are meant for educational purposes only and are not intended to replace professional medical advice, diagnosis or treatment. Do not delay care because of the content on this site. If you think you are experiencing a medical emergency, please call your doctor immediately or call 911 (if within the United States). This blog and its content are the intellectual property of QuickMD LLC and may not be copied or used without permission.

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