Systemic lupus erythematosus (SLE), commonly known as lupus, is an autoimmune disorder—an inflammatory disease in which the immune system attacks the body’s own cells. Lupus can affect most parts of the body, including the skin, brain, joints, lungs, kidneys, and blood vessels. But what is Lupus?
Let’s explore some common Lupus symptoms to look out for.
What Are the Symptoms of Lupus?
- Fever: Caused by inflammation or infection.
- Muscle and Joint Pain: Swelling and stiffness, typically in the neck, shoulders, upper arms, and upper legs.
- Rashes: Often in a butterfly shape on the face, particularly on skin exposed to sunlight.
- Chest Pain: Pain with inhalation.
- Hair Loss: Patchy bald spots.
- Kidney Inflammation: Symptoms include weight gain, swollen ankles, high blood pressure, and lowered kidney function.
- Mouth Ulcers: Painless ulcers on the roof or elsewhere in the mouth or soreness or dryness of the mouth.
- Fatigue: Persistent tiredness.
- Anemia: Lack of red blood cells to carry oxygen.
- Cognitive Issues: Forgetfulness or confusion.
- Blood Clots: Internal blood clots in the lungs, legs, heart, or brain.
- Miscarriages: Spontaneous abortions.
- Eye Issues: Dry or inflamed eyes or rashes on eyelids.
How Is Lupus Diagnosed?
Lupus is diagnosed through blood tests that check for antibodies to the body’s own cells and low numbers of white blood cells, red blood cells, and clotting blood cells. Inflammation in the blood is measured by erythrocyte (red blood cell) sedimentation rate.
How Is Lupus Treated?
Significant progress has been made in treating autoimmune disorders, including lupus. Treatments include:
FDA-Approved Medications
- Benlysta (belimumab): Approved in 2011, patients inject this drug under the skin once a week.
Immunosuppressants
- Imuran (azathiaprine)
- Cellcept (mycophenolate mofetil)
- Sandimmune (cyclosporine)
- Rheumatrex (methotrexate)
- Arava (leflunomide)
- Cytoxan (cyclophosphamide)
- Leukeran (chlorambucil)
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs):
- Aspirin
- Tylenol (acetaminophen)
- Naprosyn (naproxen)
- Motrin (ibuprofen)
- Indocin (indomethacin)
- Celebrex (celecoxib)
- Relafen (nabumetone)
Corticosteroids
These man-made medications are similar to the hormone cortisol and are used to calm inflammation. They may be applied as creams for skin rashes, injected into muscles, or taken orally for systemic inflammation.
Lupkynis (voclosporin)
FDA-approved for treating kidney inflammation associated with SLE. It works by preventing T cells, a type of white blood cell, from causing kidney damage.
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